Epidermal Growth Factor Receptor Inhibitors: A Moving Target?
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor receptor inhibitors: a moving target?
It has been over 20 years since the first agents targeting the epidermal growth factor receptor (EGFR) pathway were developed by Mendelsohn and Baselga (1). In vitro studies demonstrating that antibodies inhibiting the pathway could retard cell growth, and markedly so in some cell lines, led ultimately to clinical trials testing EGFR inhibition as a therapeutic strategy. As the EGFR pathway was...
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The process of cell division, growth, differentiation and death is a highly regulated process. Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) a member of Receptor Tyrosine Kinase (RTK) family are best known. These comprises of four receptors Erb B1/HER 1, Erb B2 / HER 2, Erb B3/ HER 3, and Erb B4 / HER 4. Of these H...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2005
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-05-1845